Introduction development of highly efficient synthetic methodologies for the construction of biologically important compounds is one of the challenges to medicinal and organic chemist. With stimulation by iodobenzene alone, a reduction of basic nerve impulse firing during exposure is followed by a transient poststimulus excitation rebound. Diacetoxyiodobenzene, also known as phenyliodineiii diacetate pida is a hypervalent. Iodobenzene diacetate, also known as periodinane, is a chemical compound containing hypervalent iodine and considered hypervalent. I think iodobenzene diacetate will be more stronger. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. In the typical condition, the three chemists used 1 or 2 mol% ph 3 pauots as the precatalyst and an oxidant formed in situ from iodobenzene diacetate and camphorsulfonic acid. The reaction mixture was poured into a large excess of iced water and stirred for 1 h.
Structure, properties, spectra, suppliers and links for. Aryl aldehydes 2 were efficiently condensed with ethylacetoacetate 1 and ammonium acetate in acetonitrile to give dihydropyridine intermediates 4. Iodobenzene diacetate ph1 oac 2 has hypervalent iodine iii compounds, are attractive oxidizing agents because of their stability and selectivity. The solvent was 2% methanol in chloroform, and most reactions were complete at room temperature between 20. The onepot, threecomponent reactions of substituted 1,3cyclohexanediones, iodobenzene diacetate and alkenes, under photochemical activation, yields fused dihydrofuran derivatives in good yield via the in situ formation of iodonium ylides. Periodinane hypervalent iodine is suited for the many oxidation and rearrangements reactions including belows to. Afterwards adjusted to ph 9 by adding a 2 n aqueous sodium hydroxide. This page was last edited on 20 october 2018, at 02. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. Exposure to iodobenzene causes an inhibition of the response to ba.
Visible lightpromoted selective oxidation of sulfides to sulfoxides catalyzed by ruthenium porphyrins with iodobenzene diacetate. Shop online for a wide selection of iodobenzene diacetate, 98%, acros organics iodobenzene diacetate, 98%, acros organics. If more ice is used a portion remains unmelted after the diazotization is completed. This is suitable for cleaving glycols and alphahydroxy ketones in ring opening and mannich reaction. Apollo scientific currently provides pricing in several currencies. To a stirred mixture of iodobenzene diacetate 1 322 mg, 1.
First aid oral exposure if swallowed, wash out mouth with water provided person is conscious. Methods and material for containment and cleaning up methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet. Distillation under reduced pressure gives 327335g 7476% of theory of iodobenzene, bp 7778c20 mm. Hypervalent iodineiii reagents in organic synthesis arkivoc. Pida can also be prepared from iodosobenzene and glacial acetic acid. Ungraded products supplied by tci america are generally suitable for common industrial uses or for research purposes but typically. Highly efficient, one pot synthesis and oxidation of hantsch. Goldiiicatalyzed direct acetoxylation of arenes with. Iodobenzene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions3. Leading manufacturer of diacetoxyiodobenzene cas no.
Sedimentwater from the tsurumi river, japan was used to determine the biodegradation of iodobenzene. You can also browse global suppliers,vendor,prices,price,manufacturers of. However, iodosobenzene diacetate alone oxidizes flavanones to flavones. Zhdankin department of chemistry and biochemistry, university of minnesota duluth, duluth, minnesota 55812, usa email. Covid19 is an emerging, rapidly evolving situation. Keywords dihydropyridines, iodobenzene diacetate, ultrasonic, microwave, onepot, formylpyrazoles 1. Diacetoxyiodobenzene 98%, c10h11io4, iodobenzene diacetate. The solvent was 2% methanol in chloroform, and most reactions were complete at room temperature between 20 and 40 hours. Useful reagent for mild, rapid cleavage of 1,3dithianes to the parent carbonyl compounds. A mild, general, convenient, and efficient onepot synthesis of 4arylpyridines 4 is described using conventional heating, ultrasound and microwave irradiation. Seema finechem industry llp is manufacturer, exporter, supplier and producer of diacetoxyiodobenzene and other speciality chemical intermediates at most competitive price. Dihydropyridines, iodobenzene diacetate, ultrasonic, microwave, onepot, formylpyrazoles 1.
Iodobenzene reacts readily with magnesium to form the grignard reagent, phenylmagnesium iodide. Inflammation of the eye is characterized by redness, watering, and itching. Iodobenzene diacetate, tech or78 3240344 from apollo. Ibda is defined as iodobenzene diacetate very rarely. Import data and price of iodobenzene under hs code 29319090. Iodosobenzene diacetate is an organic reagent used as an oxidizing agent.
This information is stored within a cookie and setting this assumes acceptance. Dce 2 ml was added, followed by adding d1mesitylene 3a 303 mg, 2. Periodinane hypervalent iodine is suited for the many oxidation and rearrangements reactions including belows to prepare complex substances. Please select the one that is most appropriate for your business. Apollo scientific home products iodobenzene diacetate, tech. Carbonyl oxidation with hypervalent iodine reagents involves the functionalization of the. Iodobenzene diacetate 322 mg, 1 mmol, aucl3 6 mg, 2 mol% were weight in a 25 ml tube. This leads to the formation of an intermediate compound called benzenediazonium. The approach employs diacetoxyiodobenzeneinduced initial dehydrogenation.
Iodobenzene 1,1 diacetate environmental precautions avoid discharge into drains or watercourses or onto the ground. To convert aniline to idobenzene, it is reacted with as catalyst. Iodobenzene reacts with chlorine to give the complex, iodobenzene dichloride, which is used as a solid source of chlorine. Fused dihydrofurans from the onepot, threecomponent. Iodobenzene diacetate is a useful reagent in the synthesis of a large variety of heterocyclic compounds. Shop online for a wide selection of iodobenzene diacetate, 98%, acros organics. If a good separation has been made not more than 12g of iodobenzene is lost with the upper layer. To convert a reactant into the product, the initial step is to understand the chemical formula. Seema finechem industry llp based in navi mumbai, india is a pioneer exporter, manufacturer and a major supplier of iodobenzene diacetate diacetoxyiodobenzene cas no. Iodobenzene diacetate 3240344 tcii0330 spectrum chemical.
The latter underwent a smooth iodobenzene diacetate iii mediated aromatization reaction in the same pot to afford 4arylpyridines 4 in good to excellent yields. Iodobenzene diacetatemediated heterodomino transformations. Aurora ka6690 daib diacetoxyiodobenzene diacetoxyiodosobenzene iodine, bisacetatokophenyl iodobenzene diacetate iodobenzene i,i diacetate iodosobenzene diacetate iodosobenzene i,i diacetate labotestbb lt00847235 phenyliodine diacetate pia diacetoxyiodobenzen dihydroxyiodo. H trifluoromethylation of quinolineamides on the c5 position with iodobenzene diacetate as the oxidizing agent zhaoyang wu state key laboratory of applied organic chemistry, key laboratory of nonferrous metal chemistry and resources utilization of gansu province, department of chemistry, lanzhou university, lanzhou, 730000 china. It can be used in the preparation of iodobenzene dichloride, which is employed as an oxidant to oxidize alcohols to carbonyl compounds and as a chlorinating agent. Phenylmagnesium iodide, like the bromide analog, is a synthetic equivalent for the phenyl anion synthon. There is no warranty of accuracy or completeness of any information contained herein. Rapid oxidation of alcohols to carbonyl compounds in solventless system using microwaves. Search results for iodobenzene diacetate at sigmaaldrich. The resulting white precipitate was filtered and washed with ether and dried in vacuum to afford analytically pure product 3.
Halobenzenes benzene and substituted derivatives fisher scientific english. Iodobenzene diacetate ibd catalyzed an quick oxidative. Iodobenzene diacetate 322 mg, 1 mmol, aucl3 6 mg, 2 mol% were weighted in a 25 ml tube. Under visible light irradiation, the carbonyl rutheniumii porphyrin complexes efficiently catalyze the selective oxidation of sulfides to sulfoxides with iodobenzene diacetate phioac 2 as the oxygen source. Carbonyl oxidation with hypervalent iodine reagents. This electrophilic intermediate may be attacked by a variety of nucleophiles or. The solution was concentrated by rotovap to leave a crude reside. Highly efficient, one pot synthesis and oxidation of. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. One use of pida is in the preparation of similar reagents by substitution of the acetate groups. All structured data from the file and property namespaces is available under the creative commons cc0 license. Slightly hazardous in case of skin contact irritant, of eye contact.
Iodobenzene diacetate ibd catalyzed an quick oxidative aromatization of hantzsch1,4dihydropyridines to pyridines under ultrasonic irradiation. It is used as an oxidizing agent in organic chemistry. Zip file containing the mol files of the most important compounds in this article. Iodobenzene has a bimodal effect on the receptor cell tuned to benzoic acid ba of the female silk moth bombyx mori. Accordingly, the chemical formula of aniline is and iodobenzene is. Lot and batch numbers can be found on a products label following the words lot or batch. Visible lightpromoted selective oxidation of sulfides to. Hazard identification emergency overview for additional information on toxicity, please refer to section 11. The latter underwent a smooth iodobenzene diacetate iii mediated aromatization.
Import data and price of iodobenzene under hs code. Useful reagent for mild, rapid cleavage of 1,3dithianes to the parent. Ungraded products supplied by tci america are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use. Diacetoxyiodobenzene, also known as phenyliodineiii diacetate pida is a hypervalent iodine chemical with the formula c 6 h 5 iococh 3 2. Fused dihydrofurans from the onepot, threecomponent reaction of 1,3cyclohexanedione, iodobenzene diacetate and alkenes. Files are available under licenses specified on their description page. Information provided on iodobenzene diacetate 3240344 is for reference only and is subject to change. View detailed import data, price, monthly trends, major importing countries, major ports of iodobenzene under hs code 29319090. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. The solution was then concentrated by rotovap to leave a crude reside which was purified by silica gel column chromatography petroleum. Hypervalent iodineiii reagents in organic synthesis viktor v. Cyclization for the synthesis of cyclopentabfurans. Predicted data is generated using the us environmental protection agencys episuite. Very hazardous in case of skin contact irritant, of eye contact irritant.
Diacetoxyiodobenzene moriarty major reference works. Iodobenzene has been shown to biodegrade anaerobically in sedimentwater slurries with reported halflives of to 87 days910. Iodobenzene is used in various cc coupling reactions. Hypervalent iodineiii reagents in organic synthesis. You also can through below form to request documents for moa,ros,1hnmr. Iodobenzene 1,1diacetate environmental precautions avoid discharge into drains or watercourses or onto the ground. Iodobenzene diacetate, iodobenzene diacetate 3240344. On the mechanism of action of cytochrome p450 journal of. Als environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. Hazard identification potential acute health effects. Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived.